Like any tool, NServiceBus has a learning curve, and there were a few problems along the way. The biggest was an issue with configuring web applications as endpoints. Each web application used the fluent configuration API in the Application_Start event handler like so:
NServiceBus.Configure.With()...
It worked fine in almost all cases. However, when one application was deployed to IIS, the configuration code was throwing inexplicable errors. My team lost about a week trying to figure out what was going on, and eventually started investigating workarounds in order to meet the deadline. Workarounds usually result in their own unique set of problems, which I desperately wanted to avoid. Finally, a long session with reflector revealed the problem:
NServiceBus.Configure.WithWeb()...
The difference between the two methods is subtle. The former tells NServiceBus to scan AppDomain.BaseDirectory for assemblies, while the latter tells NServiceBus to scan AppDomain.DynamicDirectory. The reason this affected one application in particular was because of how that application is deployed. Different versions of the application are deployed in virtual directories under the same web application in IIS, so there was a mismatch between some assembly versions.
The NServiceBus samples demonstrate the use of the WithWeb method. Had we paid more attention to the samples, we might have completely avoided this headache.